Studies on Drug Nonequivalence. VII. Bioavailability of Acetohexamide Polymorphs
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概要
- 論文の詳細を見る
The thermodynamic values of two polymorphic forms of acetohexamide (form I and form II) were calculated from solubility measurements. The transition temperature and the heat of transition were estimated to be 154°, and 230 cal./mol, respectively. In vivo absorption studies of these polymorphs were carried out in four beagle dogs, and bioavailability parameters were determined from the blood concentration versus time curves. The polymorphic form of acetohexamide did not affect the bioavailability.
- 社団法人日本薬学会の論文
- 1979-06-25
著者
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高岸 靖
塩野義製薬製造部
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黒田 耕司
Hospital Pharmacy, Kobe University School of Medicine
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高岸 靖
Production Division, Shionogi & Co., Ltd.
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梅田 常雄
Hospital pharmacy, Kobe University School of Medicine
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黒田 耕司
Hospital Pharmacy Kobe University School Of Medicine
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梅田 常雄
Hospital Pharmacy Kobe University School Of Medicine
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佐藤 耕治
塩野義製薬株式会社製造本部製剤試製部
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