スルファチアゾールの多形の転移と消化管吸収
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概要
- 論文の詳細を見る
Relationship between the transition and gastrointestinal absorption of two polymorphic forms of sulfathiazole was studied. The drug content in blood of rabbits after oral administration and intraduodenal administration of the polymorph of sulfathiazole was compared and it was found that the gastrointestinal absorption was affected by the rate of transformation of the polymorph, and the drug was absorbed from "stable" form II more efficiently than from form I when suspensions were administered orally. The effect of 0.1% gelatin on the absorption behavior was examined and conversion from form II to form I seemed slower in the presence of gelatin. From these results, it was recommended that the "stable" form II should be used in order to expect a better therapeutic efficacy in pharmaceutical preparations.
- 公益社団法人日本薬学会の論文
- 1977-02-25
著者
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横山 照由
神戸大学医学部附属病院薬剤部
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黒田 耕司
神戸大学医学部附属病院薬剤部
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梅田 常雄
神戸大学医学部附属病院薬剤部
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黒田 耕司
Hospital Pharmacy Kobe University School Of Medicine
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梅田 常雄
Hospital Pharmacy Kobe University School Of Medicine
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- スルファチアゾールの多形の転移と消化管吸収