Studies on Drug Nonequivalence. X. Bioavailability of 6-Mercaptopurine Polymorphs
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概要
- 論文の詳細を見る
The gastrointestinal absorption of 6-mercaptopurine (6-MP) polymorphs was studied in rabbits, and their absorption kinetics were analyzed. Form III of 6-MP was absorbed more efficiently from the gastrointestinal tract than form I. It was found that the absorption kinetics after oral administration of 6-MP could be satisfactorily accounted for by a two-compartment model with two consecutive first-order input steps. Form III had an extent of bioavailability about 1.5 times greater than that of form I. This result may be attributed to a difference of K_1 and/or K_a between the polymorphic forms I and III.
- 社団法人日本薬学会の論文
- 1981-01-25
著者
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浅田 昌三
Kobe Women's College of Pharmacy
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黒田 耕司
Hospital Pharmacy, Kobe University School of Medicine
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梅田 常雄
Hospital pharmacy, Kobe University School of Medicine
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黒田 勤
Hospital Pharmacy Kobe University School Of Medicine
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横山 照由
Hospital Pharmacy, Kobe University School of Medicine
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黒田 勤
Kusunoki-cho, Ikuta-ku, Kobe Pharmacy, Miki City Hospital
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黒田 耕司
Hospital Pharmacy Kobe University School Of Medicine
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浅田 昌三
Kobe Women's College Of Pharmacy
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梅田 常雄
Hospital Pharmacy Kobe University School Of Medicine
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