医薬品の物理化学的性質(第4報)消化管吸収シミュレーターにおけるバルビツール酸誘導体の透過性
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Diffusion rate constants of 23 compounds through an artificial lipid barrier were studied employing a Sartorius absorption simulator for barbituric acid derivatives (I). Acid dissociation constants and lipid-water partition coefficients were also determined spectrophotomerically. It was found that there was a parabolic dependence on log P for log k by applying equation (12).
- 公益社団法人日本薬学会の論文
- 1976-10-25
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