Statistical Study of the Model-independent Method to describe the Blood Disappearance Profile of Intravenously Administered Drugs

概要

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The applicability of the model-independent method to pharmacokinetic analysis was statistically studied. For this purpose, two kinds of data were used, i.e., plasma disappearance data for warfarin (a typical example of a triple-exponential decay) and for amoxicillin (double-exponential decay). By using statistical analysis with least-squares fitting (SALS), a nonlinear regression analysis program, curve fittings were carried out with respect to those data sets. In the case of the warfarin data, the triple-exponential equation was superior to the model-independent one in terms of both the residual sum of squares and an information criterion (AIC). However, very little difference between the two could be seen by eye when the results were drawn on graph paper. In the case of the amoxicillin data, the model-independent equation was statistically superior to the double-exponential one. The applicability of this model-independent method to pharmacokinetic analysis was thus confirmed.
公益社団法人日本薬学会の論文
1982-07-25