METABOLISM OF PEPTIDE DRUGS BY THE MICROORGANISMS IN RAT CECAL CONTENTS
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概要
- 論文の詳細を見る
The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery.
- 社団法人日本薬学会の論文
- 1995-06-15
著者
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東崎 英之
京都薬大・薬剤
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藤田 卓也
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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山本 昌
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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山本 昌
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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東崎 英之
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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江見 泰治
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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堀坂 恵里
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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堀坂 恵里
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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江見 泰治
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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