Potentiation of Antitumor Effect of Aclarubicin on Rat Hepatoma Model by Hepatic Arterially Administered Oily Dosage Forms
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概要
- 論文の詳細を見る
The antitumor effect of aclarubicin (ACR) in an oily dosage formulation composed of Lipiodol (lymphographic oil), or with linoleic acid and 1-dodecylazacycloheptan-2-one (Azone), was investigated by hepatic intra-arterial administration against Walker 256 carcinosarcoma implanted in the rat liver. Evaluation based on the grown rate of the tumor indicated that ACR was more effective on administration as Lipiodol solution or oil-in-water emulsion compared to saline aolution, but the addition of linoleic acid or Azone to Lipiodol solution did not further improve the antitumor activity of ACR. A clear correlation between the depression of the hepatic tumor growth rate and the levels of ACR and its active metabolites in the tumor tissue 24h after the hepatic intra-arterial administration was also observed.
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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吉川 広之
Department of Biopharmaceutics, Kyoto College of Pharmacy
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高田 寛治
Department of Biopharmaceutics, Kyoto College of Pharmacy
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村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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吉川 広之
Department Of Drug Dosage Form Design Faculty Of Pharmaceutical Sciences Toyama Medical & Pharma
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岡垣 琢也
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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岡垣 琢也
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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