Antitumor Activity of Timed-release Derivative of Mitomycin C, Agarose Bead Conjugate
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概要
- 論文の詳細を見る
A timed-release derivative of mitomycin C (MMC), agarose bead conjugate (MMC-AB), was synthesized using cyanogen bromide method. MMC was released successively for considerably longer period from MMC-AB in vitro and in vivo after intraperitoneal injection to mice. MMC-AB exhibited almost identical inhibitory effect against growth of Ehrlich ascites carcinoma (EAC) cells to free MMC and less toxicity to ddY mouse than free MMC. Calculated therapeutic index (LD_<10>/ED_<90>) of MMC-AB was two times greater than that of free MMC, suggesting its advantage in cancer chemotherapy. On the life span of EAC bearing ddY mouse, MMC-AB showed almost similar efficiency with that of free MMC but less activity was exhibited against BDF_1 mouse transplanted L1210 leukemia.
- 公益社団法人日本薬学会の論文
- 1978-06-25
著者
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村西 昌三
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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瀬崎 仁
京都大学
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村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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橋田 充
Faculty Of Pharmaceutical Sciences Kyoto University
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村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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小嶋 拓巳
Faculty Of Pharmaceutical Sciences Kyoto University
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