Assessment of Pharmaceutical Excipient-Induced Gastrointestinal Mucosal Damage in Rats in Vivo by Measuring the Permeation of Phenolsulfonphthalein
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概要
- 論文の詳細を見る
The effect of pharmaceutical excipients on the gastrointestinal mucosa in rats was examined by measuring the permeation of phenosulfonphthalein (phenol red), a poorly absorbed drug. The urinary recovery after oral administration of phenol red was significantly increased by pretreatment with sodium lauryl sulfate and Triton X-100 in rats. However, pretreatment with polysorbate 80,lactose, fructose, mannitol, calcium citrate, acacia, or polyethylene glycol 4000 had no apparent effect.
- 社団法人日本薬学会の論文
- 1985-08-25
著者
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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木村 聰城郎
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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中村 純三
Faculty Of Pharmaceutical Sciences Nagasaki University
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木村 聡城郎
大鵬薬品工業
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山本 昌
京都薬科大学
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山本 昌
Faculty of Pharmaceutical Sciences, Kyoto University
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木村 聰城郎
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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木村 聰城郎
Faculty Of Pharmaceutical Sciences Okayama University
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高田 重行
Pharmaceutical Development Laboratories Central Research Division Takeda Chemical Industries Ltd.
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