Absorption of Drugs from the Skeletal Muscle of the Rats. V. Effect of Potassium Ion on the Absorption of Some Anionic Drugs
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概要
- 論文の詳細を見る
Effect of potassium ion on the intramuscular absorption of some drugs has been examined using the rat thigh muscle clearance method. In the presence of K^+ (<200 mM), a specific and reversible inhibition was noted in the absorption of anionic drugs such as isonicotinic acid, PABA, and sulfa drugs. This inhibition of anionic drug absorption produced by K^+ was reversed by DNP and KCN, but was not abolished by ouabain. This inhibition was minimized by the addition of EDTA. Extracellular K^+ of high concentration produced by anionic drugs may cause the increase of Ca^<++> entry into the muscle tissue, which inhibits the drug transfer in the muscle by some unknown pharmacological actions.
- 社団法人日本薬学会の論文
- 1974-04-25
著者
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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奥村 勝彦
Hospital Pharmacy Kobe University School Of Medicine
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奥村 勝彦
Faculty of Pharmaceutical Sciences, Kyoto University
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今崎 一
Faculty of Pharmaceutical Sciences, Kyoto University
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今崎 一
Faculty Of Pharmaceutical Sciences Kyoto University
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奥村 勝彦
Faculty Of Pharmaceutical Sciences Kyoto University
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