Role of Intestinal Mucus in the Absorption of Quinine and Water-soluble Dyes from the Rat Small Intestine
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概要
- 論文の詳細を見る
Role of intestinal mucus in the absorption of quinine and four water-soluble dyes, methylene blue, bromthymol blue, bromphenol blue, and phenol red, from the rat small intestine was investigated. Immediately after pretreatment with pH 6.5 buffer solution for 10 min and recovery period of 15 min after the pretreatment, absorption experiments were carried out at pH 6.5 using the in situ perfusion technique and in vitro uptake method by the everted sacs. Considering from the results of determination of protein and neutral sugar, it seems likely that mucus was secreted during the recovery period of 15 min after the pretreatment with pH 6.5 buffer solution. All drugs examined bound to mucus prepared from intestinal washings after the recovery period of 15 min. It is suggested that the mucosal surface of the small intestine, mucus layer, has an important role in the absorptive process of quinine and four water-soluble dyes.
- 公益社団法人日本薬学会の論文
- 1978-03-25
著者
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島 勝彦
Formulation Research Department, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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村西 昌三
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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木村 聰城郎
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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中村 純三
Faculty Of Pharmaceutical Sciences Nagasaki University
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村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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木村 聡城郎
大鵬薬品工業
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木村 聰城郎
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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島 勝彦
Faculty of Pharmaceutical Sciences, Kyoto University
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村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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木村 聰城郎
Faculty Of Pharmaceutical Sciences Okayama University
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島 勝彦
Formulation Research Department Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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