Studies on Pharmaceutical Modification of Anticancer Agents. II. Enhanced Delivery of Bleomycin into Lymph by Emulsions and Drying Emulsions

概要

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The enhanced delivery into lymph of bleomycin was studied by the intraperitoneal and intramuscular injection of oil emulsified preparations. A comparison of concentration of bleomycin in thoracic duct lymph showed that W/O emulsion was the most effective and followed by O/W emulsion. An application of spray drying powder was also attempted to the enhanced delivery, and the lymph concentration was increased as compared with the injection of the aqueous solution although lower than O/W liquid emulsion. A measuring of binding to oil particles indicated that approximately 40% of bleomycin was bound to the particles of O/W liquid emulsion and of reconstituted emulsions prepared from drying products. Furthermore the clearance rates of bleomycin from the muscle were delayed about one half by W/O, O/W and reconstituted emulsion. The possible mechanism of enhanced delivery into lymph was discussed in this paper.
社団法人日本薬学会の論文
1975-12-25