Intestinal Absorption of Drugs from Solubilized Systems of Long-Chain Fatty Acids in the Rat

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The effects of long-chain fatty acids solubilized by sodium taurocholate on the absorption of various water-soluble drugs from the rat small intestine were investigated using the in situ perfusion technique. The addition of 20 mM sodium taurocholate alone or together with lower concentration of oleic acid increased the absorption of poorly absorbable procaine amide, while with higher concentration of oleic acid decreased the absorption of the drug. The addition of oleic acid and monolein significantly increased the formation of micellar complex of well absorbable 2-allyloxy-4-chloro-N-(2-diethylaminoethyl) benzamide hydrochloride (A. C. D. B.) and inhibited the absorption of it, compared to those produced by 20 mM sodium taurocholate alone. The results suggested that the effects of long-chain fatty acids on the intestinal absorption of drugs in the presence of sodium taurocholate were mediated via two mechanisms : modification of the permeability of the membrane and micellar complexation of the drug.
公益社団法人日本薬学会の論文
1976-10-25