More Clarifications concerned with the Photodynamic Action of Riboflavine on the Intestinal Absorption of Drugs in the Rat

概要

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Investigation of the effect of riboflavine photolysates on the intestinal absorption of drugs has been pursued. Absorption studies were done using in situ recirculation technique. In the presence of riboflavine photolysates the intestinal absorption of phenol red was found to be pH dependant. The colon and rectal absorption of phenol red was promoted by the presence of riboflavine photolysates. No detectable effect of riboflavine photolysates on the intestinal absorption of moderately and rapidly absorbed drugs could be seen. There was no significant effect on the release of intestinal protein, contrary to the surface active agents where they produce undesirable side effects. Riboflavine photolysates modified the membrane permeability by decreasing its resistance to the passage of drug molecules known to be absorbed with great difficulty.
公益社団法人日本薬学会の論文
1977-11-25