Absorption and Excretion of Drugs. XXVI. Effect of Water-Soluble Bases on Rectal Absorption of Sulfonamides
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概要
- 論文の詳細を見る
The rates of absorption of sulfonamides were measured in the presence of a number of water-soluble bases. The absorption rates was reduced by these bases. This reduction depends mainly upon their decrease of lipid-vehicle partition. The differences existed in their absorption at incorporating the various water-soluble bases, and these differences are related to the dielectric constants of the bases : the larger their dielectric constant, the smaller the reduction of rectal absorption. The results suggest that the drug abosrption in the presence of water-soluble bases can be interpreted by the depression of the polarity in the vehicle.
- 公益社団法人日本薬学会の論文
- 1965-08-25
著者
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村西 昌三
Faculty of Pharmaceutical Sciences, Kyoto University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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掛見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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