Sustained Release of Dibucaine from Konjac Gels after Rectal Administration to Rats
スポンサーリンク
概要
- 論文の詳細を見る
The use of konjac gls as a vehicle for sustained drug release in the form of a rectal suppository was examinied in rats. Dibucaine dispersed in the konjac gels was released in the rectum at a rate predictable from in vitro release studies. No observable destruction of rectal mucosa was noted on microscopic observation, even after two 24 hr contacts (3-week interval) with drug-free gels.
- 公益社団法人日本薬学会の論文
- 1979-10-25
著者
-
有田 隆一
Department Of Pharmacy Hokkaido University Hospital
-
有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
-
滝川 香織
Faculty of Pharmaceutical Sciences, Hokkaido University
-
滝川 香織
Faculty Of Pharmaceutical Sciences Hokkaido University
関連論文
- Transformation and Excretion of Drugs in Biological Systems. IX. Interactions between Sulfinpyrazone and Sulfonamides, and between Oxyphenbutazone and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VIII. Interactions between 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydro-pyrimidine and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VII. Effect of Biotransformation on Renal Excretion of Sulfonamides
- Transformation and Excretion of Drugs in Biological Systems. VI. Correlation between Renal Excretion and Biotransformation of Sulfisomidine and Sulfamethizole
- Transformation and Excretion of Drugs in Biological Systems. V. Correlation between Renal Excretion and Biotransformation of Sulfadimethoxine
- Effect of Pyrazolone Derivatives on the Critical Micelle Concentration of Ionic Surfactants
- Solubilities of Antipyrine Derivatives in Water and Non-polar Solvents
- Trichloroethyl Phosphate のラット消化管内における加水分解挙動
- Fluorometric Determination of Cephalexin, Cephradine, and Cephatrizine in Biological Fluids
- パルミチン酸クロラムフェニコールー結晶セルロース混合粉砕物の物理化学的性質と消化管吸収
- 溶解性,吸収性を改良した新しいジフェニルヒダントイン剤 (抗けいれん剤の発達薬理)
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. II. Preparation and Tissue Distribution in Mice of Microsphere-entrapped 5-Fluorouracil
- Solubility Characteristics of Weak Bases and Their Hydrochloride Salts in Hydrochloric Acid Solutions
- Transformation and Excretion of Drugs in Biological Systems. XI. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (3)
- Transformation and Excretion of Drugs in Biological Systems. X. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (2)
- Transformation and Excretion of Drugs in Biological Systems. I. Renal Excretion Mechanisms of Sulfonamides. (I)
- 抗酸化剤の研究 : (第4報)ω, ω′-Bis-p-aminophenol誘導体の合成ならびにその抗酸化性
- Sustained Release of Dibucaine from Konjac Gels after Rectal Administration to Rats
- Effect of Formulation Additives on the Dissolution Behavior of Tetracycline Antibiotics
- Solution and Partition Behaviors of Colchicine
- Fluorometric Determination of Cephalexin in Urine
- The Effect of Charges on Permeabilities of Drugs through Collagen Membranes
- Effect of Additives on the Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals
- Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals Studied by Infrared Spectrophotometric Method
- A Comparison of Solubility Characteristics of Free Bases and Hydrochloride Salts of Tetracycline Antibiotics in Hydrochloric Acid Solutions
- Effect of Crystal Forms on the Dissolution Behavior and Bioavailability of Tetracycline, Chlortetracycline, and Oxytetracycline Bases
- Sustained Release of Theophylline from Konjac Gels
- The Permeation of Benzodiazepines through Synthetic Membranes
- Interactions of Aluminum, Magnesium, and Calcium Ions with Nalidixic Acid
- Spectrophotometric Studies on Accelerated Hydrolysis of Iodine In the Presence of Polyvinylpyrrolidone
- Change in Apparent Permeability of Iodine in the Presence of Polyvinylpyrrolidone
- Analysis of Permeation Profiles of Drugs from Systems containing Micelles
- Controlled Release of Butamben (Buryl p-aminobenzoate) through Silicone Membrane by Means of Complexation and Micellar Solubilization
- Controlled Drug Permeation. II. Comparative Permeability and Stability of Butamben and Benzocaine
- Physical Properties of Pyrimidine and Purine Antimetabolites. II. Permeation of 5-Fluorouracil and 1-(2-Tetrahydrofuryl)-5-fluorouracil through Cellophane, Collagen, and Silicone Membranes
- Physical Properties of Pyrimidine and Purine Antimetabolites. I. The Effects of Salts and Temperature on the Solubility of 5-Fluorouracil, 1-(2-Tetrahydrofuryl)-5-fluorouracil, 6-Mercaptopurine, and Thioinosine
- Metabolism of Thiamphenicol and Comparative Studies of Its Urinary and Biliary Excretion with Chloramphenicol in Various Species
- Absorption and Excretion of Drugs. XXXIV. An Aspect of the Mechanism of Drug Absorption from the Intestinal Tract in Rats
- Absorption and Excretion of Drugs. XXXIII. The Correlation between the Absorption of Barbituric Acid Derivatives from the Rat Small Intestine and Their Binding to the Mucosa
- Absorption and Excretion of Drugs. XXXII. Absorption of Barbituric Acid Derivatives from Rat Small Intestine.
- Absorption and Excretion of Drugs. XXXI. On the Relationship between Partition Coefficients and Chemical Structures of Barbituric Acid Derivatives.
- Absorption and Excretion of Drugs. XXX. Absorption of Barbituric Acid Derivatives from Rat Stomach.
- Further Investigation on the Interaction of Sulfonamides with Non-steroidal Anti-inflammatory Agents in Dogs
- Dissolution Behavior and Gastrointestinal Absorption of Sulfamethoxazole from Sulfamethoxazole-Polyvinylpyrrolidone Coprecipitates
- Dissolution Behavior and Gastrointestinal Absorption of Dicumarol from Solid Dispersion Systems of Dicmarol-Polyvinylpyrrolidone and Dicumarol-β-Cyclodextrin
- Influence of Dietary Components on the Bioavailability of Phenytoin
- Dissolution Mechanisms of Drug-Polyvinylpyrrolidone Coprecipitates in Aqueous Solution
- Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
- Dissolution Behaviors and Gastrointestinal Absorption of Tolbutamide in Tolbutamide-Polyvinylpyrrolidone Coprecipitate
- Dissolution Behaviors and Gastrointestinal Absorption of Phenytoin in Phenytoin-Polyvinylpyrrolidone Coprecipitate
- Studies on the Pharmaceutical Potentiation of Drugs. I. p-Aminosalicylic Acid Derivatives.
- Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution
- テトラサイクリンの数種の固相の物性と消化管吸収
- Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride
- Studies on Percutaneous Absorption of Drugs. III. Percutaneous Absorption of Drugs through Damaged Skin
- Chemical Assay of Thiamphenicol and Chloramphenicol
- Studies on Percutaneous Absorption of Drugs. II. Time-Course of Cutaneous Reservoir of Drugs
- Transformation and Excretion of Drugs in Biological Systems. IV. Reabsorption of Biliary Metoclopramide-N^4-glucuronide and -N^4-sulfonate from Rabbit Intestine
- Transformation and Excretion of Drugs in Biological Systems. III. Separatory Determination of Metoclopramide and Its N^4-Glucuronide and N^4-Sulfonate in Rabbit Urine and Bile
- 抗酸化剤の研究(第3報) : ω, ω′-Bis(2(3 or 4)-hydroxyphenyl)alkane類およびω, ω′-Bis-(2-hydroxy-3(4 or 5)-methylphenyl)alkane類の合成ならびにその抗酸化性
- 抗酸化剤の研究(第2報) : ω, ω′-Bis(2,5-dihydroxyphenyl)alkane類およびω, ω′-Bis(2-hydroxy-5-methoxyphenyl)alkane類の合成ならびにその抗酸化性
- 抗酸化剤の研究 : (第1報)ω, ω′-Bis(2,3,4-trihydroxyphenyl)alkane類の合成ならびにその抗酸化性
- Release Characteristics of Nifedipine Sustained-Release Granules in Vitro and in Healthy Subjects(Pharmaceutical)
- Studies on Percutaneous Absorption of Drugs. I.
- スルフイソキサゾールーポリビニルピロリドン共沈物の溶解性と消化管吸収
- Inhibitory Effect of Polyvinylpyrrolidone on the Crystallization of Drugs
- A Comparison of Bioavailability of Free Bases and Hydrochloride Salts of Chlortetracycline, Demethylchlortetracycline, and Methacycline
- Transformation and Excretion of Drugs in Biological Systems. II. Transformation of Metoclopramide in Rabbits
- Simultaneous Vascular and Luminal Perfusion of Rat Small Intestine
- Intestinal Absorption of Several β-Lactam Antibiotics. II. Absorption Characteristics of Amino-penicillins and Amino-cephalosporins
- 医薬品の吸収と排泄に関する研究(第28報) : 油脂溶液からのサルファ剤の直腸吸収
- Absorption and Excretion of Drugs. XXII. Absorption of Isoniazid and its Derivatives
- Studies on the Pharmaceutical Potentiation of Drugs. II. p-Aminosalicylic Acid Derivatives.
- 1-Cyclohexyl-5-n-Butyl-2,4,6-trioxoperhydropyrimidineのタンパク結合
- Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXVI. Effect of Water-Soluble Bases on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXV. On the Mechanism of Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXI. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (3). Excretion from the Kidney.
- Absorption and Excretion of Drugs. XX. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (2). Absorption from Rat Small Intestine.
- Absorption and Excretion of Drugs. XIX. Some Pharmacokinetic Aspects of Absorption and Excretion of Sulfonamides. (1). Absorption from Rat Stomach.