医薬品の吸収と排泄に関する研究(第28報) : 油脂溶液からのサルファ剤の直腸吸収

概要

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In order to clarify the mechanism of rectal absorption of sulfa drugs from fatty oils, this absorption was examined by perfusion of rat rectum with fatty oils of different nature, using higher fatty acids, their esters, and higher alcohols. Absorption rate of sulfisoxazole becomes greater as the drug in the fatty oil becomes more easily liberated into the excretion fluid. Absorption rate of sulfapyridine is not affected greatly by the nature of fatty oils, while that of sulfathiazole becomes smaller with fatty oils from which the drug is more easily liberated into the excretion fluid. These results seem to indicate that drug absorption from fatty oils takes two different processes ; that of absorption through the rectal membrane after being liberated into the excretion fluid and that absorbed directly from the fatty oil through the rectal membrane.
公益社団法人日本薬学会の論文
1966-04-25