Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride
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概要
- 論文の詳細を見る
The existence of the two crystalline forms of chlortetracycline hydrochloride (CTC-HCI) was confirmed by infrared spectroscopy and X-ray diffraction. From the dissolution studies with crystalline powder and compressed disk, an appreciable difference in the dissolution behavior in water was detected between the two forms. In order to determine the effect of polymorphism on the gastrointestinal absorption of CTC-HCl, blood plasma levels obtained in rabbits after intraduodenal administration and cumulative amounts excreted in human subjects after oral administration of the two forms were compared. The results indicated that polymorphic state of CTC-HCl significantly influences bioavailability of the CTC-HCl.
- 公益社団法人日本薬学会の論文
- 1974-03-25
著者
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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宮崎 正三
東日本学園大学薬学部
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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伊藤 圭二
Hokkaido College Of Pharmacy
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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伊藤 圭二
Shizuoka College of Pharmacy
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