スルホンアミド類の胆汁排泄(第1報)スルファジメトキシンの胆汁排泄

概要

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In order to study the fate of sulfadimethoxine in the bile of a guinea pig, sulfadimethoxine was administered intravenously and unchanged sulfadimethoxine, its N^4-acetate, N^1-glucuronide, and N^4-glucuronide were separately determined in the bile. About 40% of the administered dose was excreted in the bile in 5 hr as total sulfadimethoxine and about 20% as N^4-glucuronide, which is the major metabolite if the bile. After the administration of sulfadimethoxine and its N^4-glucuronide into the guinea pig duodenum, the blood level and the biliary excretion were quantitatively studied. These results suggested that N^4-glucuronide is absorbed from the intestine as sulfadimethoxine after hydrolysis. It is obvious that the enterohepatic circulation of sulfadimethoxine is present in the guinea pig.
公益社団法人日本薬学会の論文
1974-09-25