Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
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概要
- 論文の詳細を見る
The effects of sodium carboxymethylcellulose (CMC), sodium arginate (SA), methylcellulose (MC) and polyvinylpyrrolidone (PVP) on the intestinal absorption of acetaminophen in situ were investigated in rats. Among the macromolecular additives, only PVP exhibited an inhibitory effect on the absorption of the drug. Studies in vitro (solubility and dialysis experiments) showed that there is an interaction between acetaminophen and PVP. The inhibitory effect of PVP on the intestinal absorption of acetaminophen was suppressed by the addition of urea. Dialysis data showed that urea tends to reduce the binding between acetaminophen and PVP.
- 公益社団法人日本薬学会の論文
- 1979-05-25
著者
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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関川 彬
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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関川 彬
Faculty Of Pharmaceutical Sciences Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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堀 了平
Departments of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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伊藤 圭二
Hokkaido Institute of Pharmaceutical Sciences
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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伊藤 圭二
Hokkaido College Of Pharmacy
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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