Control of Release Rate of Bleomycin from Polylactic Acid Microspheres by Additives
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概要
- 論文の詳細を見る
Polylactic acid (PLA) microspheres containing bleomycin were prepared by a solventevaporation process. The release rate of bleomycin from PLA microspheres was very small. The release profiles of the drug from microspheres prepared by using L-and DL-isomers and PLA of different molecular weights did not differ significantly for up to 120 h. The release rate of the drug could be greatly enhanced by incorporating fatty acid esters as additives in the microspheres. It was found that the release rate of the drug could be controlled by using different additives and by adjusting the amount of the additive. Scanning electron microscopic observations suggested that the additive was uniformly distributed in the microspheres as small droplets. The enhanced release rate of the drug in the presence of the additives can be attributed to the highly porous structure of the PLA matrix through which the drug is released by diffusion.
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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従二 和彦
城西大・薬
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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久保田 美穂
熊本大学医学部附属病院薬剤部
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従二 和彦
Department of Pharmacy, Kumamoto University Hospital
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緒方 遵子
Faculty of Pharmaceutical Sciences, Kumamoto University
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久保田 美穂
Faculty of Pharmaceutical Sciences, Kumamoto University
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緒方 遵子
Faculty Of Pharmaceutical Sciences Kumamoto University
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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