Release Profiles of 5-Fluorouracil and Its Derivatives from Polycarbonate Matrices in Vitro
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概要
- 論文の詳細を見る
Release profiles of 5-fluorouracil (5-FU), 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur, tegafur) and 1,3-bis-(tetrahydro-2-furanyl)-5-fluorouracil (FD-1) from poly-(ethylene carbonate) and poly (propylene carbonate) pellets were examined in vitro. Because of poor compatibility of 5-FU with polycarbonates, 5-FU was quickly released from the pellets. Release of ftorafur from pellets of both polycarbonates was sustained. Release profiles of FD-1 from polycarbonate pellets were complex but extended. Release of ftorafur and FD-1 from pellets of a 9 : 1 mixture of poly (ethylene carbonate) and poly-(propylene carbonate) was less sustained than those from the individual polymers.
- 公益社団法人日本薬学会の論文
- 1982-04-25
著者
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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吉田 泰彦
東洋大工
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川口 健夫
Faculty of Pharmaceutical Sciences, Josai University
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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従二 和彦
Department of Pharmacy, Kumamoto University Hospital
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川口 健夫
Faculty Of Pharmaceutical Sciences Josai University
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井上 祥平
Department Of Synthetic Chemistry Faculty Of Engineering University Of Tokyo
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吉田 泰彦
Department of Applied Chemistry, Faculty of Engineering, Tohyo University
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吉田 泰彦
東洋大
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吉田 泰彦
Department Of Applied Chemistry Faculty Of Engineering Tohyo University
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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