Adsorption of Mexiletine onto Activated Charcoal in Macrogol-Electrolyte Solution
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概要
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Adsorption studies in vitro of mexilletine onto activated charcoal were performed in macrogol (polyethylene glycol)-electrolyte solutoin (PEG-ELS) and JP XII disintegration medium No. 2 (second medium). Mexiletine was adsorbed more extensively onto activated charcoal in PEG-ELS than that in JP XII second medium. The maximum adsorptive capacity of activated charcoal for the durg was 328 and 284 mg per gram of charcoal in PEG-ELS and JP XII second medium, respectively. In addition, the equilibrium constant of activated charcoal estimated according to the Langmuir equation was 0.079 and 0.034 l per gram of charcoal in PEG-ELS and JP XII second medium, respectively. Adsorption of mexiletine onto activated charcoal was decreased by omitting macrogol, sodium sulfate or sodium bicarbonate from a standard PEG-ELS formulation. Oral activated charcoal will be useful in combination with whole bowel irrigation with PEG-ELS in mexiletine overdose because of its excellent adsorbability in the solution.
- 1993-04-15
著者
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弟子丸 恵実
熊本大学医学部附属病院薬剤部
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有森 和彦
Department of Pharmacy, Kumamoto University Hospital
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古川 恵美子
Department Of Pharmacy Kumamoto University
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弟子丸 恵実
Department of Pharmacy, Kumamoto University
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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