スルフイソキサゾールーポリビニルピロリドン共沈物の溶解性と消化管吸収

概要

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The dissolution rate of sulfisoxazole was markedly increased in sulfisoxazole-polyvinylpyrrolidone (PVP) coprecipitate. The X-ray diffraction revealed that sulfisoxazole in the coprecipitate did not have its crystal structure. When the ratio of PVP to sulfisoxazole was 1 : 10,the coprecipitation did not take place. The dissolution rate of sulfisoxazole in the coprecipitate was greater when the ratio of PVP to the drug was higher. The concentration of sulfisoxazole released from the coprecipitate into water reached supersaturation within a few minutes, then passed the peak, and decreased gradually indicating recrystallization. The solution remained supersaturated for a long period. The dissolution rate of sulfisoxazole was greater when PVP of smaller molecular weight was used for the preparation of the coprecipitate. After oral dose of these test preparations to human subjects, excretion rate and cumulative amount of total sulfisoxazole from the coprecipitate were greater than those of other test preparations, indicating that sulfisoxazole was absorbed faster after administration of the coprecipitate.
公益社団法人日本薬学会の論文
1978-01-25