Fluorometric Determination of Cephalexin, Cephradine, and Cephatrizine in Biological Fluids
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概要
- 論文の詳細を見る
Intensely fluorescent products were formed from cephalexin and cephradine in acidic solution containing hydrogen peroxide by hydrolysis at high temperature. A fluorescent product was formed from cephatrizine in solutions containing mercuric chloride by warming at 60° for 50 min after cleavage of the β-lactam ring with 1N NaOH. Each of the fluorescent products was readily extracted with ethyl acetate or an acetone-chloroform mixture from neutral solutions, and could be partitioned into alkaline solution. The urinary excretion of these antibiotics in human volunteers after oral administration was investigated using these new methods.
- 社団法人日本薬学会の論文
- 1979-10-25
著者
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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宮崎 勝已
Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University
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荻野 修
Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University
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宮崎 勝已
北海道大学附属病院薬剤部
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