Controlled Drug Permeation. II. Comparative Permeability and Stability of Butamben and Benzocaine
スポンサーリンク
概要
- 論文の詳細を見る
Local anesthetic agents, benzocaine and butamben were compared for their permeabilities to silicone membrane and stabilities against hydrolytic degradations in 0.05N NaOH solutions. Butamben permeated through the membrane from the suspension to the same extent as benzocaine in spite of smaller solubility in water. Calculated stability of butamben in suspension was about 10 times greater than benzocaine due to smaller hydrolytic rate constant and smaller solubility. These properties of butamben may be favorable for the delivery system using a silicone membrane as a release-controlling barrier.
- 公益社団法人日本薬学会の論文
- 1977-05-25
著者
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従二 和彦
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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中野 真汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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