Permeation and Hydrolysis of Trichloroethyl Phosphate in the Rat Intestine

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The hydrolysis and permeation of trichloroethyl phosphate were examined in vitro by using everted sacs of rat intestine. The concentration of trichloroethanol was higher in serosal solutions than in mucosal solutions at a high concentration of the phosphate ester whereas the opposite was the case at a low concentration of the ester at pH 7.4. The concentration of trichloroethanol in serosal solutions differed in different regions of the small intestine. The phosphate ester permeated into serosal solutions as such at pH 3.5. Therefore the ester is expected to permeate into serosal solutions as such and then to be hydrolyzed at a high concentration of the phosphate ester at pH 7.4. Percentage losses of the phosphate ester from the intestinal loop in situ differed slightly in different regions of intestinal tracts. The ester is expected to be hydrolyzed in the intestinal lumen before absorption under normal conditions, or be absorbed as such when present at a high concentration.
社団法人日本薬学会の論文
1981-01-25