Trichloroethyl Phosphate のラット消化管内における加水分解挙動
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概要
- 論文の詳細を見る
Hydrolysis of trichloroethyl phosphate, a model compound of phosphate esters, was examined in vitro using mucosal fluid of intestine and mucosal homogenate of the gastro-intestinal tract of rats. Hydrolytic activity in mucosal fluid varied depending on pH and prewashing. Hydrolytic activity in the mucosa decreased in the order of duodenum, jejunum, and ileum. Some hydrolysis took place by mucosal homogenate of stomach at pH 7.4 whereas little hydrolysis was observed at pH 1.2. Therefore, the ester is expected to be hydrolyzed in the mucosal fluid in intestine before absorption or be hydrolyzed in the mucosa after it is taken up intact.
- 社団法人日本薬学会の論文
- 1978-01-25
著者
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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谷口 誠
Faculty Of Pharmaceutical Sciences Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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谷口 誠
北海道大学薬学部
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中野 眞汎
北海道大学薬学部
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有田 隆一
北海道大学薬学部
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有田 隆一
北海道大学医学部附属病院薬剤部
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