Preparation and Evaluation in Vitro of Polylactic Acid Microspheres Containing Local Anesthetics
スポンサーリンク
概要
- 論文の詳細を見る
The use of DL-polylactic acid (PLA) microspheres as a means to achieve sustained release of butamben, tetracaine, and dibucaine was examined in vitro. As a first step, PLA solutions in an organic solvent containing the drug were dispersed in viscous aqueous solutions, then microspheres were formed by a solvent-evaporation process. The release mechanism was examined by scanning electron microscopy. The effects of polymer solvents and nonsolvents on the microsphere characteristics and release patterns from the microspheres were examined. The effects of drug contents and microsphere size on release patterns were also investigated.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
-
従二 和彦
Faculty of Pharmaceutical Sciences, Hokkaido University
-
中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
-
従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
-
中野 眞汎
Kumamoto University Hospital
-
脇山 尚樹
Faculty of Pharmaceutical Sciences, Hokkaido University
-
脇山 尚樹
Faculty Of Pharmaceutical Sciences Hokkaido University
関連論文
- Sustained Release of Sulfamethizole from Agar Beads after Oral Administration to Humans
- Synthesis and Evaluation in Vitro of 4-Acetamidophenyl Phosphate
- Trichloroethyl Phosphate のラット消化管内における加水分解挙動
- Disposition of Enantiomers of sultopride in a Human, Rats and Rabbits
- Release Characteristics of a Free Polyunsaturated Fatty Acid from an Oily Lymphographic Agent
- Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclopyrimidinenucleosides in Intestinal Tissue Homogenates
- Differential Effects of Acyclothymidine, a Potent Pyrimidine Nucleoside Phosphorylase Inhibitor, on the Pharmacokinetics of Doxifluridine in Rabbits via Oral Administration
- Studies on 2', 3'-Dideoxy-2', 3'-didehydropyrimidine Nucleosides. II. : N_4-Benzoyl-2', 3'-dideoxy-2', 3'-didehydrocytidine as a Prodrug of 2', 3'-Dideoxy-2', 3'-didehydrocytidine (DDCN)
- マイクロスフィア, エマルジョンなどによる抗がん薬の効果, 増強 : 薬剤の有効な投与方法に関する研究
- Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents