Preparation and Evaluation in Vitro and in Vivo of Polylactic Acid Microspheres Containing Doxorubicin
スポンサーリンク
概要
- 論文の詳細を見る
Polylactic acid microspheres containing doxorubicin were prepared by a solvent evaporation process and release patterns of the drug from the microspheres were examined in vitro. Microspheres with greater drug contents released more drug. The release rate of the drug after the initial burst was found to be small, so that prolonged release was obtainable. It was also found that the wettability of the microspheres might influence the release rate. Venous plasma levels of the drug following intra-arterial administration into dog liver were considerably lower than those following administration of the drug solution. Microangiography revealed embolization due to the microspheres in peripheral arteries in the liver.
- 公益社団法人日本薬学会の論文
- 1985-01-25
著者
-
市原 知文
熊本大学第二外科
-
中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
-
従二 和彦
城西大・薬
-
従二 和彦
Faculty Of Pharmaceutical Sciences Josai University
-
従二 和彦
Department of Pharmacy, Kumamoto University Hospital
-
緒方 遵子
Faculty of Pharmaceutical Sciences, Kumamoto University
-
市原 知文
Second Department of Surgery, Kumamoto University Hospital
-
森 且孝
Second Department of Surgery, Kumamoto University Hospital
-
赤木 正信
Second Department of Surgery, Kumamoto University Hospital
-
緒方 遵子
Faculty Of Pharmaceutical Sciences Kumamoto University
-
森 且孝
Second Department Of Surgery Kumamoto University Hospital
-
中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
関連論文
- 142 膵頭十二指腸切除術における再建法の評価(第28回日本消化器外科学会総会)
- 322 肝内結石症に対する外科的治療(第27回日本消化器外科学会総会)
- 304 上部胆管癌の治療成績(第27回日本消化器外科学会総会)
- 45. 乳頭部癌の進展様式(第12回日本胆道外科研究会)
- Sustained Release of Sulfamethizole from Agar Beads after Oral Administration to Humans
- 45. TACE 療法が奏効した進行肝癌の1例(第17回九州地区小児外科悪性腫瘍研究会)
- Microparticulate bombardment system を用いた抗原含有微粒子の免疫処置に関する研究
- 36.胆道閉鎖症術後患児に対する部分的脾塞栓術 : 3例の経験(第1回小児脾臓研究会)
- 19.稀なる部位に転移をみた神経芽腫stage IV Aの2例(第21回九州小児外科学会)
- 示-119 食道・胃静脈瘤に対する系統的塞栓術の有用性について(第37回日本消化器外科学会総会)
- 355 進行肝癌に対する治療 : ポリ乳酸マイクロスフィアとリピオドール中シスプラチン懸濁液の併用による肝動脈塞栓術(第37回日本消化器外科学会総会)
- 291 進行肝癌に対する治療 : 特にポリ乳酸マイクロスフィアによる肝動脈塞栓術の有用性について(第32回日本消化器外科学会総会)
- 56.先天性胆道閉鎖症患児の胃食道静脈瘤出血に対する経回結腸静脈的食道静脈瘤塞栓術(TIO)と内視鏡的硬化療法の併用療法(第13回胆道閉鎖症研究会)
- W1-6 食道静脈瘤に対する硬化療法の選択 : 特に当科に於ける選択基準、施行方法と合併症について(第30回日本消化器外科学会総会)
- 100 小児肝悪性腫瘍症例の検討とアクラルビシンマイクロスフェアの使用経験
- 38. 肝内結石症に対する手術療法ならびに術後内視鏡的治療(第14回日本胆道外科研究会)
- 26.切除不能肝芽腫に対する T.A.C.E.(Transcatheter Arterial Chemo-Embolization)の経験(第14回九州地区小児外科悪性腫瘍研究会)
- 3.クッシング症候群を呈した副腎皮質腺癌の1乳児例(第14回九州地区小児外科悪性腫瘍研究会)
- 191 モノクローナル抗体にて認識される新しい腫瘍マーカー CA125 の検討(第25回日本消化器外科学会総会)
- 5 食道静脈瘤の病態とその治療(第25回日本消化器外科学会総会)
- Synthesis and Evaluation in Vitro of 4-Acetamidophenyl Phosphate
- Trichloroethyl Phosphate のラット消化管内における加水分解挙動
- 15. 悪性閉塞性黄疸に対する経皮経肝胆道生検の検討(第8回日本胆道外科研究会)
- 75 経十二指腸的乳頭形成症例の検討(第16回日本消化器外科学会総会)
- 26.切除不能肝芽腫に対する肝動脈紡紮チュービング及び油性制癌剤動注の試み(第13回九州地区小児外科悪性腫瘍研究会)
- 薬物皮膚適用後の皮内挙動解明のためのウサギ耳灌流法に関する基礎的研究
- Disposition of Enantiomers of sultopride in a Human, Rats and Rabbits
- Release Characteristics of a Free Polyunsaturated Fatty Acid from an Oily Lymphographic Agent
- Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclopyrimidinenucleosides in Intestinal Tissue Homogenates
- Differential Effects of Acyclothymidine, a Potent Pyrimidine Nucleoside Phosphorylase Inhibitor, on the Pharmacokinetics of Doxifluridine in Rabbits via Oral Administration
- Studies on 2', 3'-Dideoxy-2', 3'-didehydropyrimidine Nucleosides. II. : N_4-Benzoyl-2', 3'-dideoxy-2', 3'-didehydrocytidine as a Prodrug of 2', 3'-Dideoxy-2', 3'-didehydrocytidine (DDCN)
- マイクロスフィア, エマルジョンなどによる抗がん薬の効果, 増強 : 薬剤の有効な投与方法に関する研究
- Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents
- Reversible Azomethine Bond Cleavage of Guanabenz in Acidic Solutions at Body Temperature
- Preparation and Evaluation of Sustained Release Tablets Prepared with α-Starch(Pharmaceutical,Chemical)
- Degradation of Bromazepam by the Intestinal Microflora(Pharmaceutical,Chemical)
- PLASMA CONCENTRATION PROFILE OF DIAZEPAM AFTER ORAL ADMINISTRATION OF THE OPEN-RING FORM OF DIAZEPAM TO MAN
- Thymidineの鼻粘膜透過に関する研究
- 微粒子を用いたDDS
- 皮膚適用後のフルルビプロフェンの皮下移行性に関する研究
- 市販製剤品質比較試験法の基準の作成(病院薬局協議会)
- 市販製剤品質比較試験法の基準の作成(病院薬局協議会)
- 市販製剤品質比較試験法の基準の作成
- 88. 先天性胆管拡張症の3例 (成人例)(第11回日本胆道外科研究会)
- The Permeation of Benzodiazepines through Synthetic Membranes
- Interactions of Aluminum, Magnesium, and Calcium Ions with Nalidixic Acid
- Spectrophotometric Studies on Accelerated Hydrolysis of Iodine In the Presence of Polyvinylpyrrolidone
- Change in Apparent Permeability of Iodine in the Presence of Polyvinylpyrrolidone
- Analysis of Permeation Profiles of Drugs from Systems containing Micelles
- Controlled Release of Butamben (Buryl p-aminobenzoate) through Silicone Membrane by Means of Complexation and Micellar Solubilization
- Physical Properties of Pyrimidine and Purine Antimetabolites. II. Permeation of 5-Fluorouracil and 1-(2-Tetrahydrofuryl)-5-fluorouracil through Cellophane, Collagen, and Silicone Membranes
- 徐放性製剤 (医薬品の新しい製剤技術)
- 高分子を用いた薬物制御放出剤形
- Adsorption of Mexiletine onto Activated Charcoal in Macrogol-Electrolyte Solution
- Adsorption of Imipramine onto Activated Charcoal and a Cation Exchange Resin in Macrogol-Electrolyte Solution
- Dissolution Behavior and Gastrointestinal Absorption of Dicumarol from Solid Dispersion Systems of Dicmarol-Polyvinylpyrrolidone and Dicumarol-β-Cyclodextrin
- Mechanism of Enhancement of the Release Rate of Aclarubicin from Poly-β-hydroxybutyric Acid Microspheres by Fatty Acid Esters
- Modification of the Release Rate of Aclarubicin from Polylactic Acid Microspheres by Using Additives
- Control of Release Rate of Bleomycin from Polylactic Acid Microspheres by Additives
- Preparation and Evaluation in Vitro and in Vivo of Polylactic Acid Microspheres Containing Doxorubicin
- In Vitro Adsorption Characteristics of Bile Salt Anions by Activated Carbon Beads for Oral Administration
- Examination of Natural Gums as Matrices for Sustained Release of Theophylline
- Preparation and Drug Adsorption Characteristics of Activated Carbon Beads Suitable for Oral Administration
- Preparation and Evaluation in Vitro and in Vivo of Polylactic Acid Microspheres containing Dibucaine
- Influence of Physicochemical Properties of Polylactic Acid on the Characteristics and in Vitro Release Patterns of Polylactic Acid Microspheres containing Local Anesthetics
- Preparation and Evaluation in Vitro of Polylactic Acid Microspheres Containing Local Anesthetics
- Identification of the Decomposition Products of Hydralazine Hydrazones with Three Endogenous Ketones and Kinetic Study of the Formation of 3-Methyl-s-triazolo [3,4-a] phthalazine from Hydralazine and Pyruvic Acid
- Influence of Dietary Components on the Bioavailability of Phenytoin
- Dissolution Mechanisms of Drug-Polyvinylpyrrolidone Coprecipitates in Aqueous Solution
- Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
- Dissolution Behaviors and Gastrointestinal Absorption of Tolbutamide in Tolbutamide-Polyvinylpyrrolidone Coprecipitate
- Dissolution Behaviors and Gastrointestinal Absorption of Phenytoin in Phenytoin-Polyvinylpyrrolidone Coprecipitate
- Enhanced Absorption of Phenobarbital from Suppositories Containing Amino Acid and Choline Salts of Phenobarbital(Pharmaceutical,Chemical)
- 原末変更に伴うジゴキシン製剤の生物学的同等性の検討
- Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution
- Adsorption and Prevention of Gastrointestinal Absorption of Nalidixic Acid by Activated Carbon Beads
- Agarose-Encapsulated Adsorbent Beads for Direct Hemoperfusion : Preparation and in Vitro Evaluation
- Selective Adsorption by Activated Charcoal Preparations for Adsorbates of Medical Interest Ranging in Molecular Weight from About 100 to 800
- Preparation and Evaluation in Vitro and in Vivo of Polycarbonate Microspheres Containing Dibucaine
- Preparation and Evaluation in Vitro of Polycarbonate Microspheres Containing Local Anesthetics
- 36. 肝管癌および上部胆管癌の治療(第13回日本胆道外科研究会)
- Enhanced Absorption of Phenobarbital from Suppositories containing Phenobarbital-β-Cyclodextrin Inclusion Complex
- スルフイソキサゾールーポリビニルピロリドン共沈物の溶解性と消化管吸収
- Inhibitory Effect of Polyvinylpyrrolidone on the Crystallization of Drugs
- A Comparison of Bioavailability of Free Bases and Hydrochloride Salts of Chlortetracycline, Demethylchlortetracycline, and Methacycline
- ケノデオキシコール酸カプセル剤の品質比較試験
- セファドロキシルカプセル剤の溶出試験
- Increased Transport of Theohylline into Gastrointestinal Lumen and Gastrointestinal Dialysis by Activated Charcoal in Rats with Hepatic Cirrhosis
- Hydrolytic and Associative Behavior of Aromatic Amides in Aqueous Solution
- Release Profiles of 5-Fluorouracil and Its Derivatives from Polycarbonate Matrices in Vitro
- Fluorometric Determination of Amoxicillin
- Intestinal Absorption Mechanisms of Ampicillin Derivatives in Rats. I. Intestinal Absorption of Ampicillin Derivatives
- Fluorometric Determination of Ampicillin and Aminobenzylpenicilloic Acid in Presence of Pivampicillin in Body Fluids
- Studies on Molecular Interaction in Solution. III. Salting Behavior of Cyclic Amides and Cyclic Conjugated Ketones in Tetraalkylammonium Salt Solutions
- Evaluation of Hydroxyethylcellulose as a Hydrophilic Swellable Material for Delayed-Release Tablets
- Enhanced Absorption of Phenobarbital from Suppositories Containing Phenobarbital Povidone Coprecipitate
- Studies on Molecular Interaction in Solution. I. Effects of Organic Ions on the Solubility of 8-Methoxycaffeine
- Transport to Intestinal Lumen and Peritoneal Cavity of Intravenously Administered Aprindine in Rats
- Pharmacokinetics of Theophylline and Phenobarbital during Peritoneal Dialysis Compared with Intestinal Dialysis in Rats
- Comparison of Transport of Procainamide and N-Acetylprocainamide from Blood into the Intestinal Lumen with That into the Peritoneal Cavity in Rats