Transformation and Excretion of Drugs in Biological Systems. I. Renal Excretion Mechanisms of Sulfonamides. (I)
スポンサーリンク
概要
- 論文の詳細を見る
In order to understand the renal excretion mechanisms of sulfonamides, some renal clearance studies were undertaken with two sulfonamides, sulfanilamide and sulfisoxazole, in rabbits. From the results of inhibitory experiments by iodopyracet, it was found that only sulfisoxazole was actively secreted into the tubule by p-aminohippurate mechanism. Using this method it becomes possible to calculate and separately estimate the net amounts secreted and reabsorbed. The result calculated with sulfisoxazole suggested a significant amount secreted and a higher amount reabsorbed.
- 公益社団法人日本薬学会の論文
- 1969-12-25
著者
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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大和田 栄治
北海道大学薬学部
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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高橋 克幸
Faculty of Pharmaceutical Sciences, Hokkaido University
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大和田 栄治
Faculty of Pharmaceutical Sciences, Hokkaido University
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