併用投与時のスルフイソキサゾール家兎血中濃度におよぼすホモスルファミンの影響

概要

論文の詳細を見る
In order to obtain wider biophaomaceutical knowledge on drug interactions, the effect of 4-homosulfanilamide on the blood 1evels of sulfisoxazole after simultaneous administration to rabbits were investigated. After the ora1 administration of su1fisoxazo1e with equimolar 4-homosu1fanilamide, the total blood levels of sulfisoxazole equivalents rapidly increased and then fluctuated or slow1y rose for about 10 hr. These patterns differed considerably from that observed after the oral administration of sulfisoxazole alone. To understand these phenomena the effect of 4-homosulfanilamide on the dissolution, intestinal absorption, blood elimination, and renal excretion of sulfisoxazole were examined. It was assumed from these results that rapidly elevating and fluctuating blood levels of sulfisoxazole were partly due to the change of the dissolution behavior by 4-homosulfanilamide in the gastro-intestina1 tract. The inhibition of renal excretion of sulfisoxazole by p-sulfamoylbenzoic acid, which is metabolized from 4-homosulfailamide in the body, also might maintain the blood levels of sulfisoxazole.
公益社団法人日本薬学会の論文
1974-01-25