Absorption and Excretion of Drugs. XXXII. Absorption of Barbituric Acid Derivatives from Rat Small Intestine.
スポンサーリンク
概要
- 論文の詳細を見る
Absorption of barbituric aicd derivatives from rat small intestine was investigated systematically, and it was found that the absorption did not depend on chemical structure and lipid solubility so much as in the gastric absorption, but no specialized absorption mechanism was demonstrated. The pH-partition hypothesis was partially operative, but pH absorption profile had an optical pH range in all derivatives investigated and N-methyl series which have higher lipid solubilty than the corresponding oxy series were absorbed slowly than expected. These phenomena of in situ experiments which are assumed exceptional to pH-partition hypothesis were correlated significantly with the in vitro binding to mucosal preparations of rat small intestine.
- 公益社団法人日本薬学会の論文
- 1967-12-25
著者
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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小西 良士
帝国製薬(株)製剤開発研
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小西 良士
Faculty of Pharmaceutical Sciences, Nagasaki University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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掛見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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