Absorption and Excretion of Drugs. XXX. Absorption of Barbituric Acid Derivatives from Rat Stomach.
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概要
- 論文の詳細を見る
The absorption of the unionized forms of barbituric acid derivatives from rat stomach was found to be a first order process and varied with the differences in the chemical structures. N-methylation and O-S displacement markedly affected the gastric absorption. The mediated physicochemical factor was partition coefficient to organic solvent. Effect of pH of drug solution also influenced the absorption of especially readily absorbed derivatives. In respect to ionized forms, the similarity in rate constants was observed among all series of derivatives, and the mechanism involved was assumed to be a physical diffusion through pores. From these observations, it was concluded that all types of barbituric acid derivatives are absorbed from rat stomach by a relatively simple physical process, which is in good agreement with pH-partition process suggested by Brodie, et al.
- 公益社団法人日本薬学会の論文
- 1967-10-25
著者
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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小西 良士
帝国製薬(株)製剤開発研
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小西 良士
Faculty of Pharmaceutical Sciences, Nagasaki University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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掛見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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