Interaction of Drugs with Bile Components. II. Effect of Bile on the Absorption of Indomethacin and Phenylbutazone in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of endogenous bile on the intestinal absorption of indomethacin and phenylbutazone was investigated in control rats and in bile fistula rats. Oral administration of both drugs in suspension gave lower plasma concentrations in bile fistula rats than in control animals. On the other hand, studies in which solutions of the two drugs were administered intraduodenally to control and bile fistula rats indicated that bile had no effect on their plasma levels. These results suggest that bile plays an important role in the dissolution step in the absorption processes of indomethacin and phenylbutazone.
- 公益社団法人日本薬学会の論文
- 1980-01-25
著者
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井上 ひとみ
Faculty Of Pharmaceutical Science Josai University
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宮崎 正三
東日本学園大学薬学部
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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山平 智浩
Faculty of Pharmaceutical Science, Josai University
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灘井 種一
Faculty Of Pharmaceutical Sciences Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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山平 智浩
Research Center, Taisho Pharmaceutical Co., Ltd.,
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山平 智浩
Research Center Taisho Pharmaceutical Co. Ltd.
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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