External Control of Drug Release. IV. : Controlled Release of 5-Fluorouracil from a Hydrophilic Polymer Matrix by Microwave Irradiation
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概要
- 論文の詳細を見る
A polymeric system capable of delivering 5-fluorouracil (5-FU) at increased rates on demand by external microwave irradiation was developed. Sustained-release systems were made by incorporating 5-FU into an ethylene-vinyl alcohol copolymer. When exposed to release medium, the delivery systems released the drug slowly and continuously. Upon exposure to microwave irradiation, the drug was released at a much higher rate. Release rates returned to base line levels when the microwave irradiation was discontinued.This study demonstrated that release rates of 5-FU from a polymer matrix can be increased at desired times by external microwave irradiation.
- 1989-01-25
著者
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宮崎 正三
北海道医療大学薬学部
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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横内 千鶴子
Faculty of Pharmaceutical Science, Higashi-Nippon Gakuen University
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横内 千鶴子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
-
高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
-
宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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