Studies on Metabolism of 2-Methyl-3-o-tolyl-4(3H)-quinazolinone. II. Physiological Disposition and Metabolic Fate of 2-Methyl-3-o-tolyl-4 (3H)-quinazolinone.
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概要
- 論文の詳細を見る
The physiological disposition and the metabolic fate of hypnotic, 2-methyl-3-o-tolyl-4 (3H)-quinazolinone (MTQ), were studied in man, rat and rabbit. MTQ is rapidly absorbed from the gastrointestinal tract in man and rat. The concentraton of the drug in depot fat is remarkably high compared with that in other tissues in rat. The drug is almost completely metabolized in the body and the rate of biotransformation of the drug is relatively slow. Glucuronides excretion after oral administration of 200 mg./kg. of MTQ was about 20% in a rabbit.
- 社団法人日本薬学会の論文
- 1963-03-25
著者
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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赤木 満洲雄
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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桶谷 米四郎
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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須賀 哲彌
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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高田 昌彦
Pharmacy, Hokkaido University Hospital
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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須賀 哲彌
Faculty Of Pharmaceutical Sciences School Of Medicine Hokkaido University
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赤木 満洲雄
Faculty Of Pharmaceutical Sciences Hokkaido University
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桶谷 米四郎
Faculty Of Pharmaceutical Sciences School Of Medicine Hokkaido University
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