Studies on Mercapturic Acids. Effect of Some Chemical Compounds on the Activities of Glutathione-conjugating Enzymes
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概要
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1. For the purpose of clarifying the mechanism of mercapturic acid formation, properties of enzymes which catalyzed the conjugation of GSH with benzyl chloride (BzCl), bromobenzene (BrPh) and 3,4-dichloronitrobenzene (DCNB) were examined in the liver of rats. 2. In addition to the supernatant fraction, a microsomal fraction was necessary for the enzymic conjugation of GSH with BrPh. 3. GSH-conjugating activity with BzCl was depleted in the liver of rats treated with BzCl. Either GSH-conjugating activity toward DCNB or BrPh did not show a significant change after the administration of each compound. 4. GSH-conjugating activity toward BrPh markedly increased in the liver of rats treated with phenobarbital, and its ratio of the stimulation was paralleled with that of aniline-hydroxylating activity. 5. It was assumed that increase of the activity of GSH-conjugation with BrPh by the treatment with phenobarbital was due to the induction of a microsomal oxygenase system.
- 公益社団法人日本薬学会の論文
- 1970-01-25
著者
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赤木 満洲雄
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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須賀 哲弥
Faculty Of Pharmaceutical Sciences Josai University
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赤木 満洲雄
Faculty Of Pharmaceutical Sciences Hokkaido University
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