Effect of 3-Amino-1,2,4-triazole on the Formation of Triglyceride in Liver Slice

概要

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The effect of 3-amino-1,2,4-triazole (AT) on the formation of liver triglyceride (TG) was studied by using liver slices. In the liver of rat received AT (1 g/kg, i.p.), the incorporation of ^<14>C-acetate into TG decreased about 45 per cent when compared with that of the control, though the incorporation of ^<14>C-palmitate into TG did not differ from that of the control. In addition, the incorporation of ^<14>C-acetate into total fatty acid decreased about 30 per cent in the liver of the received with AT. In in vitro experiment, the incorporation of ^<14>C-acetate into TG was inhibited about 40 per cent in the presence of 50 mM AT in incubation mixture and the inhibition was dependent to the concentration of AT. One of the causes of decrease of liver TG level induced by AT may be due to the inhibition of fatty acid synthesis in the liver.
公益社団法人日本薬学会の論文
1977-09-25