Biological Fate of Tritiated p-Biphenylmethyl-(dl-tropyl-α-tropinium)-bromide in the Rat

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Absorption, distribution and excretion of tritiated p-biphenylmethyl-(dl-tropyl-α-tropinium) bromide (^3H-BTTB) in the rat were investigated. After the intravenous injection of ^3H-BTTB, half life of the radioactivity in blood was 7 min at first 30 min. Higher radioactivities were incorporated in kidney, liver, pancreas and spleen. Almost negligible radioactivity was seen in amniotic fluid or fetus. After the intramuscular injection of ^3H-BTTB, 6.62% and 60.16% of the radioactivity were excreted in urine and feces, respectively, at 96 hr. The fact may indicate that ^3H-BTTB is mainly excreted in bile. It may be suggested that these behaviors in biological disposition are attributed to have a large molecular weight and to be a quaternary ammonium compound.
公益社団法人日本薬学会の論文
1971-11-25