Metabolism of Quaternary Ammonium Compounds. II. Microautoradiographic Studies on the Effect of CCl_4 on the Intralobular Distribution of Tritiated BTTB in Mice Liver

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The intralobular distribution of ^3H-labeled p-biphenylmethyl-(dl-tropyl-α-tropinium)-bromide (^3H-BTTB) and the effect of CCl_4-injury on its distribution were studied in mice mainly by means of microautoradiographic technique. It was established that ^3H-BTTB was mostly concentrated in the cytoplasm of hepatic parenchymal cells and that this drug distributed homogeneously over whole the intralobular area. In CCl_4-treated mice, uptake of ^3H-BTTB was markedly decreased in the liver and, on the other hand, was apparently increased in the kidney. In addition, the decrease in the uptake of this drug by CCl_4-treated liver occurred widely within the liver lobules and more significant decreases were found especially in the central zones of lobule. During the course of preparation of microautoradiographic tissue sections, the degree of released radioactivity in CCl_4-treated livers was inclined to increase than that of the controls.
公益社団法人日本薬学会の論文
1974-12-25