Effect of 3-Amino-1,2,4-triazole on Carbon Tetrachloride-induced Necrosis

概要

論文の詳細を見る
Various enzyme activities in the rat serum and liver were determined and the effect of 3-amino-1,2,4-triazole (AT) on CCl_4-induced necrosis was studied. Serum transaminase (GOT and GPT) activities were markedly increased by the injection of CCl_4 (0.1 ml/100 g, i.p.). The increase fell about 60 per cent with both the pre- and post-treatment of AT (100 mg/100 g, i.p.). It was demonstrated by biochemical and histological technique that the treatment with AT also repressed the fatty liver which occurrs along with liver necrosis. The effect of CCl_4 and AT on subcellular distribution of acid phosphatase was examined. AT repressed the release of enzyme from light mitochondrial fraction to supernatant fraction caused by CCl_4. AT significantly depressed the release of enzyme from the liver lysosomes by freezing and thawing in both the control-and CCl_4-treated rat. These results indicate that AT shows a depressing effect on fatty liver, a stabilizing effect on lysosomes, and a repression on liver necrosis.
公益社団法人日本薬学会の論文
1977-08-25