Study of the Interactions between Sulfamethizole and Alclofenac, Diclofenac or Tiaprofenic Acid in Rats(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
In this study, the effects of three non-steroidal anti-inflammatory drugs, alclofenac, diclofenac and tiaprofenic acid, on the plasma level of sulfamethizole were investigated in rats. The persistence of sulfamethizole in plasma was prolonged by coadministration of each anti-inflammatory drug. In experiments to investigate the renal excretion of sulfamethizole, the clearance ratio of sulfamethizole was markedly decreased after infusion of each anti-inflammatory drug. From these results, it is speculated that prolongation of the persistence of sulfamethizole in plasma by alclofenac, diclofenac or tiaprofenic acid is mainly caused by competitive interactions between sulfamethizole and alclofenac, diclofenac or tiaprofenic acid at the renal secretory level.
- 社団法人日本薬学会の論文
- 1987-02-25
著者
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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千葉 一基
北海道医療大学薬学部
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千葉 一基
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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菊地 敏
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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西村 成勲
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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樋口 尚代
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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菊地 敏
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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樋口 尚代
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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西村 成勲
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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