Fibrinogen Microspheres as Novel Drug Delivery Systems for Antitumor Drugs
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概要
- 論文の詳細を見る
Fibrinogen microspheres containing 5-fluorouracil (5-FU) were prepared and evaluated as a novel drug delivery system. The shape of the microspheres was invariably spherical. The average diameters were 3.9 and 1.1 μm and the drug contents in the microspheres were 16.1 and 6.1%, for the microspheres prepared at 90 and 160℃, respectively. Release of the drug from fibrinogen microspheres was slow after the initial burst, and the drug release continued over 5d. These results indicated that the drug-loaded fibrinogen microspheres could be prepared providing a sustained release property in vitro. The antitumor activity of fibrinogen microspheres containing 5-FU was evaluated against Ehrlich ascites carcinoma in mice. The mean survival time of the group receiving the microspheres was larger than that of the control group, though essentially the same as that of the free 5-FU-treated group. Fibrinogen microspheres show good biocompatibility and should be useful as a novel drug carrier in injectable delivery systems for antitumor drugs.
- 社団法人日本薬学会の論文
- 1986-03-25
著者
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宮崎 正三
北海道医療大学薬学部
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森本 雍憲
Faculity Of Pharmaceutical Sciences Josai University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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橋口 典生
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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杉山 美恵子
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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高田 昌彦
北海道医療大 薬
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橋口 典生
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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杉山 美恵子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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