マススペクトロメトリーによる薬物の代謝物に関する研究(第1報) : スルフォンアミド剤のN-アセチル体の同定

概要

論文の詳細を見る
The mass spectrometry has proved useful for the identification of a small amount of substances, such as in the detection of metabolites of various drugs in biological material. As the first step in the separation of metabolites, examinations were made to reduce complicated technique using sulfanilamide N-acetate which is one of metabolites of some sulfanilamide derivatives. In the mass spectra of sulfanilamide derivatives, the most intense peaks are M-64 (-SO_2) and M-65 (-SO_2-H), and in the mass spectra of their N-acetates, peaks of M-64 and M-65 also appear. From these characteristic peaks, identification of N-acetates in the metabolites of sulfanilamide derivatives is usually possible with less than 1 mg of acetone extract from the residues obtained by evaporation of urine to dryness.
公益社団法人日本薬学会の論文
1970-11-25