小腸からのスルファニル酸の血管・リンパ管への移行におよぼすテトラサイクリンならびに2-3の添加剤の影響

概要

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Effect of various permeability modifying agents, such as bile salts, disodium ethylenediaminetetraacetate (EDTA-2Na), tetracycline, and sodium lauryl salfate, on the intestinal absorption of sulfanilic acid, normally poorly absorbable marker, was examined in rat small intestine in vivo. Presence of any one of these agents in the gut lumen markedly increased the transfer of sulfanilic acid to the thoracic duct lymph. Transfer to the tail vein was similarly increased except in the presence of EDTA-2Na. Good correlation was observed between this increase of transfer and the previously reported values of the apparent blood to gut lumen exsorption rate constant of the intravenously injected sulfanilic acid obtained under the concurrent perfusion of these agents in the small intestinel. In the case of lymphatic transfer, however, saturable tendency was noted at higher values of apparent exsorption rate constant.
公益社団法人日本薬学会の論文
1976-05-25