Mass Spectrometryによる製剤分析(第7報) : 解熱鎮痛剤の分析その3 : フェナセチン, ピリナジン, パスの高分解能質量スペクトル

概要

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There are numerous organic compounds which possess both hydroxyl and amino groups in their molecule. Since O and NH_2 both have a mass number of 16,it becomes a problem which had been eliminated in fragmentation. The analysis of their fragmentation is often carried out by their labeling with ^2H, ^<18>O or ^<15>N but labeling with isotopes is rather limited and the procedure is often difficult. Following previous reports on the mass spectrometry of aromatic compounds having both hydroxyl and amino groups in their molecule, particularly in those of antipyretics such as acetophenetidine (4-ethoxyacetanilide), pyrinazine (4-hydroxyacetanilide), and 4-aminosalicylic acid, their spectra were measured with a doublefocusing high-resolution mass spectrometer and their fragmentation was examined.
社団法人日本薬学会の論文
1967-04-25