ラットにおける同時あてはめを適用したアセトヘキサミドとその代謝物, ヒドロキシヘキサミドの相互変換モデル解析
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概要
- 論文の詳細を見る
An interconversion model which incorporated a first-pass metabolism was applied to the disposition kinetics for acetohexamide and its reversible metabolite, hydroxyhexamide, in the rat. Four fundamental clearances, CL_<10>, CL_<12>, CL_<20> and CL_<21> were calculated from four area under the plasma concentration-time curve values. Simultaneous computer multi-lines fitting of the plasma concentration-time data and adequacy of pharmacokinetic parameters in this model were tested by using an iterative nonlinear least squares regression program, MULTI.
- 公益社団法人日本薬学会の論文
- 1988-11-25
著者
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中江 裕子
神戸女子薬科大学
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浅田 昌三
神戸女子薬科大学
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中江 裕子
Kobe Women's College Of Pharmacy
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浅田 昌三
Kobe Women's College Of Pharmacy
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長嶺 幸子(旧姓
神戸女子薬科大学
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