p-(±)-α-Hydroxyethylbenzenesulfonamide及びp-(±)-α-Hydroxyethylbenzenesulfonylurea誘導体のラット血漿中における酸化的代謝物
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概要
- 論文の詳細を見る
The oxidized metabolites appeared in the rat plasma after intravenous administration of benzenesulfonamide (Ia), 1-cyclohexyl-3-benzenesulfonylurea (Ib) and 1-n-butyl-3-benzene-sulfonylurea (Ic) with a (±)-α-hydroxyethyl substituent at the para position were investigated. The metabolically produced ketones were identified with those of authentic samples by comparing their high performance liquid chromatographic retention times. On the other hand, Ib (hydroxyhexamide) and its major metabolite, IIb (acetohexamide) extracted from the rat plasma, were identified by gas chromatography-mass spectrometry after trimethyl-silylation. These alcohols and respective ketones are presumably related to reversible drug-metabolite in rats.
- 公益社団法人日本薬学会の論文
- 1987-11-25
著者
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浅田 昌三
神戸女子薬科大学
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浅田 昌三
Kobe Women's College Of Pharmacy
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乾 幸子
神戸女子薬科大学
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乾 幸子
Kobe Women's College Of Pharmacy
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