Reversible Pharmacokinetic Profiles of Canrenoic Acid and Its Biotransformed Product, Canrenone in the Rat
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概要
- 論文の詳細を見る
Pharmacokinetic profiles of canrenoic acid (CRA) and canrenone (CR), the reversible metabolite of CRA, were studied in the rat after intraportal (pv) administration in comparison with those after intravenous (iv) administration using an interconversion model In the clearances for the irreversible loss, CL_<20> of CR was larger then CL_<10> of CRA. Nevertheless, the real plasma clearance of CR was less than that of CRA. The distribution volume V_1 of CRA was almost close to the real distribution volume V_<ss, real, D> of CRA at the steady state. The hepatic available fraction of CRA, F_<H1> and sequential hepatic available fraction of generated metabolite, F_<H2>, were estimated. Simultaneous computer multi-line fitting of plasma concentration-time data was carried out and the adequacy of pharmacokinetic parameters in this model was tested using the iterative nonlinear least-squares regression program, MULTI.
- 公益社団法人日本薬学会の論文
- 1990-04-25
著者
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浅田 昌三
Kobe Women's College of Pharmacy
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中江 裕子
Kobe Women's College Of Pharmacy
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浅田 昌三
Kobe Women's College Of Pharmacy
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大多和 朋子
Kobe Women's College of Pharmacy
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大多和 朋子
Kobe Women's College Of Pharmacy
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